Faculty
Education:
Professional Experience:
Classes:
Awards & Honors:
Research Interests:
Nanobiophotonics: Plasmonics, Surface-enhanced Raman spectroscopy, Nanofabrication, Nanofluidics
Hyperspectral imaging: Raman/SERS microscopy, Two-photon fluorescence lifetime imaging, Active/structured illumination microscopy, Compressive sensing imaging, Environmental Sensing
Microsystems: N/MEMS, Lab-on-a-chip
Plasmonic Engineering: Hierarchical nanoporous gold (HNPG), Label-free DNA biomarker sensing, Intracellular sensor network, Molecular trapping, Photodynamic and photothermal therapy, Gene therapy
Novel Hyperspectral Imaging: Active/structured illumination, Computational multispectral Infrared imaging
Neural Probe for Deep Brain Stimulation and Recording: Flexible Optitrode with integrated optical and electrical channels.
Group members: PI: Wei-Chuan Shih; Postdocs: Jianbo Zeng, Greggy Santos; PhD students: Jingting Li, Fusheng Zhao, Yulung Sung, Masud Arnob, Pratik Motwani (Co)
Funded Research:
Selected Publications:
Selected Refereed Journal publication (**: Corresponding author)
Yulung Sung, Jenn Jeang, Chia-Hsiung Lee, and Wei-Chuan Shih**, “Fabricating optical lenses by 3D inkjet printing and heat-assisted in-situ curing of polydimethylsiloxane for smartphone microscopy,” (submitted).
Ming Li, Yong Du, Fusheng Zhao, Jianbo Zeng, Chandra Mohan, and Wei-Chuan Shih**, “Reagent- and separation-free measurements of urine creatinine concentration by stamping surface-enhanced Raman scattering (S-SERS),” (submitted).
Ji Qi, Pratik Motwani, Jianbo Zeng, John C Wolfe, and Wei-Chuan Shih**, “Morphological, plasmonic, and SERS characterization of DC-sputtered gold nanoislands,” (submitted).
Wei-Chuan Shih** and Kate L Bechtel, “Non-invasive glucose sensing by transcutaneous Raman spectroscopy,” (submitted).
Greggy M Santos, Fusheng Zhao, Jianbo Zeng, Ming Li, and Wei-Chuan Shih**, “Label-free, zeptomole cancer biomarker detection by surface-enhanced fluorescence on nano porous gold disk plasmonic nano particles,” (submitted).
Fusheng Zhao, Jianbo Zeng, Greggy M Santos, and Wei-Chuan Shih**, “In situ patterning of hierarchical nanoporous gold structures by in-plane dealloying, ” Materials Science and Engineering B (in revision).
Wei-Chuan Shih**, “A study of constrained regularization and its performance on non-invasive glucose sensing using Raman spectroscopy,” 2014 Journal of Innovative Optical Health Sciences (Accepted).
Jianbo Zeng, Fusheng Zhao, Ming Li, Chien-Hung Li, T. Randall Lee, and Wei-Chuan Shih**, “Morphological control and plasmonic tuning of nanoporous gold nanoparticles by surface modifications,” Journal of Materials Chemistry C DOI: 10.1039/C4TC02328E (First published online 11/14/2014).
Ji Qi, Kate L Bechtel, and Wei-Chuan Shih**, “Automated image curvature assessment and correction for high-throughput Raman spectroscopy and microscopy,” Biomedical Spectroscopy and Imaging 3(4): 359-368, 2014.
Md Masud Parvez Arnob, Fusheng Zhao, Jianbo Zeng, and Wei-Chuan Shih**, “Laser rapid thermal annealing enables tunable plasmonics in nanoporous gold nanoparticles,” Nanoscale 6(21), 12470-12475, 2014.
Narendran Sudheendran*, Ji Qi*, Eric D. Young, Alexander J. Lazar, Dina C. Lev, Raphael E. Pollock, Kirill V. Larin, Wei-Chuan Shih**, “High throughput Raman spectral imaging complements optical coherence tomography for tumor boundary detection,” Laser Physics Letters 11:105602, 2014 (*: Equal contribution).
Jianbo Zeng, Ji Qi, Fuquan Bai, Jorn Yu, and Wei-Chuan Shih**, “Analysis of ethyl and methyl centralite vibrational spectra for mapping organic gunshot residue,” Analyst 139(17), 4270-4278, 2014.
Jianbo Zeng, Fusheng Zhao, Chien-Hung Li, Yifei Li, Yan Yao, T. Randall Lee, and Wei-Chuan Shih**, “Internal and external morphology-dependent plasmonic properties in nanoporous gold disks,” RSC Advances 4, 36682-36688, 2014.
Ming Li, Fusheng Zhao, Jianbo Zeng, Ji Qi, Jing Lu, and Wei-Chuan Shih**, “Microfluidic surface-enhanced Raman scattering (SERS) sensor with monolithically integrated nanoporous gold disk (NPGD) arrays for rapid and label-free biomolecular detection,” Journal of Biomedical Optics 19(11), 111611, 2014.
Ji Qi, Jianbo Zeng, Fusheng Zhao, Steven Hsesheng Lin, Balakrishnan Raja, Ulrich Strych, Richard C. Willson, and Wei-Chuan Shih**, “Label-free, in situ SERS monitoring of individual DNA hybridization in microfluidics,” Nanoscale 6(15), 8521-8526, 2014.
Jing Yang, Xuebin Tan, Wei-Chuan Shih, and Mark Cheng, “A sandwich substrate for ultrasensitive SERS spectroscopic detection of folic acid / methotrexate,” Biomedical Microdevices 2014 DOI: 10.1007/s10544-014-9871-3 (Published on-line 5/25/14).
Fusheng Zhao, Jianbo Zeng, Md Masud Parvez Arnob, Po Sun, Ji Qi, Pratik Motwani, Mufaddal Gheewala, Chien-Hung Li, Andrew Paterson, Uli Strych, Balakrishnan Raja, Richard C. Willson, John C. Wolfe, T. Randall Lee, and Wei-Chuan Shih**, “Monolithic NPG nanoparticles with large surface area, tunable plasmonics, and high-density internal hot-spots,” Nanoscale 6, 8199-8207, 2014.
Ji Qi and Wei-Chuan Shih**, “Performance of line-scan Raman microscopy for high-throughput chemical imaging of cell population,” Applied Optics 53(13), 2881-2885, 2014.
Peter Liu*, Ji Qi*, Wei-Chuan Shih1**, and Kirill Larin2**, “Improvement of tissue analysis and classification using Optical Coherence Tomography combined with Raman spectroscopy,” Journal of Innovative Optical Health Sciences 2014, DOI: 10.1142/S1793545815500066 (In Press) (*: equal contribution; 1**: corresponding author; 2**: corresponding author).
Ming Li, Jing Lu, Ji Qi, Fusheng Zhao, Jianbo Zeng, Jorn Chi-Chung Yu, and Wei-Chuan Shih**, “Stamping surface-enhanced Raman spectroscopy for label-free, multiplexed, molecular sensing and imaging,” Journal of Biomedical Optics 19(5): 050501, 2014.
Greggy M. Santos, Fusheng Zhao, Jianbo Zeng, and Wei-Chuan Shih**, “Characterization of nanoporous gold disks for photothermal light harvesting and light-gated molecular release,” Nanoscale 6(11), 5718-5724, 2014.
Ji Qi, Pratik Motwani, Mufaddal Gheewala, Christopher Brennan, John C. Wolfe, and Wei-Chuan Shih**, “Surface-enhanced Raman spectroscopy using monolithic nanoporous gold disk substrates,” Nanoscale 5: 4105-4109, 2013. (Journal cover)
Ji Qi, Jingting Li, and Wei-Chuan Shih**, “High-speed hyperspectral Raman imaging for label-free compositional microanalysis,” Biomedical Optics Express 4(11): 2376-2383, 2013.
Ji Qi and Wei-Chuan Shih**, “Parallel Raman microspectroscopy using programmable multi-point illumination,” Optics Letters 37(8): 1289-1291, 2012.
Szu-Te Lin, Jack C. Wolfe, John A. Dani, and Wei-Chuan Shih**, “Flexible optitrode for localized light delivery and electrical recording,” Optics Letters 37(11): 1-3, 2012.
Albert B. Andrews, Wei-Chuan Shih, Oliver C. Mullins, and N. Koyo, “Molecular size determination of coal-derived asphaltene by fluorescence correlation spectroscopy,” Applied Spectroscopy: 65(12): 1348-1356, 2011.
Wei-Chuan Shih, Kate L Bechtel and Michael S Feld, “Intrinsic Raman spectroscopy for quantitative biological spectroscopy Part I: Theory and simulations,” Optics Express 16(17): 12726-12736, 2008.
Kate L Bechtel, Wei-Chuan Shih and Michael S. Feld, “Intrinsic Raman spectroscopy for quantitative biological spectroscopy Part II: Experimental applications,” Optics Express 16(17): 12737-12745, 2008.
Wei-Chuan Shih and Albert B. Andrews, “Infrared contrast of crude oil covered water surfaces,” Optics Letters 33(24): 3019-3021, 2008.
Wei-Chuan Shih and Albert B. Andrews, “Thermal infrared contrast of native and crude oil covered water surfaces,” Optics Express 16(4): 10535-10542, 2008.
Wei-Chuan Shih, Kate L Bechtel and Michael S Feld, “Constrained regularization: A new method for multivariate calibration,” Analytical Chemistry, 79(1): 234-239, 2007.
Obrad R. Šćepanović, Kate L. Bechtel, Abi S. Haka, Wei-Chuan Shih, Taewoon Koo, Andrew J. Berger, Michael S. Feld, “Determination of uncertainty in parameters extracted from single spectroscopic measurements,” Journal of Biomedical Optics, 12(6), 064012, 2007.
Wei-Chuan Shih, Sang-Gook Kim and George Barbastathis, “High resolution electrostatic analog tunable grating with a single-mask fabrication process,” IEEE/ASME Journal of Microelectromechanical Systems, vol. 15, no. 4, pp. 763-769, 2006.
Annika Enejder, Tom Scecina, Jeankun Oh, Martin Hunter, Wei-Chuan Shih, Slobadan Sasic, Gary Horowitz and Michael S. Feld, “Raman spectroscopy for non-invasive glucose measurements,” Journal of Biomedical Optics, 10(3), 031114, 2005.
Wei-Chuan Shih, Chee Wei Wong, Yungbae Jeon, Sang-Gook Kim and George Barbastathis, “MEMS tunable gratings with analog actuation,” Information Sciences, 149(1-3):31-40, 2003.
Books:
Wei-Chuan Shih**, “Hybrid fabrication makes better plasmonic nanostructures for SERS,” Photonics Spectra, August, 2013.
Wei-Chuan Shih, Kate L. Bechtel, and Michael S Feld, “Quantitative Biological Raman Spectroscopy,” in Handbook of Optical Sensing of Glucose in Biological Fluids and Tissues, Editor: Valery V. Tuchin (Taylor & Francis 2008).
Wei-Chuan Shih, Kate L Bechtel, Michael S Feld, Mark A Arnold, Gary W Small, “Introduction to spectroscopy for noninvasive glucose sensing,” in Analytical Chemistry of In Vivo Glucose Measurements; Cunningham, D.; Stenken, JA, Eds.; Wiley Chemical Analysis Series (2009).
Wei-Chuan Shih, Kate L Bechtel, Michael S Feld, “ Non-invasive glucose sensing with Raman spectroscopy,” in Analytical Chemistry of In Vivo Glucose Measurements; Cunningham, D.; Stenken, JA, Eds.; Wiley Chemical Analysis Series (2009).
Patent/Patent Applications:
Refereed Conference Proceedings:
News:
Major grants:
- DOI Award 2015
- NIH R21 grant 2014
- NSF CAREER Award 2012
- NASA CAREER Award 2012
- GoMRI-RFPII 2012
Multiple positions for PhD Research Assistant and Postdoc (Start immediately):
Suitable expertise: Optics, photonics, plasmonics, spectroscopy, imaging, FDTD, microfluidics, nanofabrication, microfabrication, biophotonics, biodemical optics.