Faculty

Wei-Chuan Shih
Dr. Wei-Chuan Shih
Assistant Professor
W328 Engineering Building 2
Houston, TX 77204-4005
Phone: 713-743-4454 | Fax: 713-743-4444
Email: wshih [at] uh [dot] edu

Education: 

Ph.D., MIT

Professional Experience: 

Assistant Professor, Electrical and Computer Engineering (Primary)/ Biomedical Engineering (Joint), 2009-present
Schlumberger Research Fellow, Schlumberger-Doll Research, 2007-2009

Classes: 

ECE 6342 Digital Signal Processing
ECE 6338 Optical and Ultrasonic Imaging
ECE 6397 Special Topics: Optical Imaging and Spectroscopy
ECE 3337 Electrical Engineering Analysis/ Signals & Systems
ECE 6339 Biophotonics

Awards & Honors: 

MIT Martin Fellowship for Sustanability, MIT, 2005
NSF CAREER Award, NSF, 2012
NASA Early Career Faculty Award, NASA, 2012
Award of Excellence in Research and Scholarship, University of Houston, 2013
NIH Study Section Instrumental and System Development, National Institute of Health, 2011-
NSF Regular and SBIR panels, National Science Foundation

Research Interests: 

Nanobiophotonics: Plasmonics, Surface-enhanced Raman spectroscopy, Nanofabrication, Nanofluidics

Hyperspectral imaging: Raman/SERS microscopy, Two-photon fluorescence lifetime imaging, Active/structured illumination microscopy, Compressive sensing imaging, Environmental Sensing

Microsystems: N/MEMS, Lab-on-a-chip

Plasmonic Engineering: Hierarchical nanoporous gold (HNPG), Label-free DNA biomarker sensing, Intracellular sensor network, Molecular trapping, Photodynamic and photothermal therapy, Gene therapy

Novel Hyperspectral Imaging: Active/structured illumination, Computational multispectral Infrared imaging

Neural Probe for Deep Brain Stimulation and Recording: Flexible Optitrode with integrated optical and electrical channels.

Group members: PI: Wei-Chuan Shih; Postdocs: Jianbo Zeng, Greggy Santos; PhD students: Jingting Li, Fusheng Zhao, Yulung Sung, Masud Arnob, Pratik Motwani (Co)

Funded Research: 

NSF CAREER Award 2012 ($400,000) http://nsf.gov/awardsearch/showAward.do?AwardNumber=1151154
NASA CAREER Award 2012 ($600,000) http://www.nasa.gov/offices/oct/early_stage_innovation/grants/2012_space_tech_research_opps.html
GoMRI-RFPII 2012 ($740,000) http://gulfresearchinitiative.org/2012/bp-sponsored-gulf-of-mexico-research-initiative-awards-new-grants/
NIH R21 2014 ($425,000)
DOI 2015 ($890,000)

Selected Publications: 

Selected Refereed Journal publication (**: Corresponding author)

Yulung Sung, Jenn Jeang, Chia-Hsiung Lee, and Wei-Chuan Shih**, “Fabricating optical lenses by 3D inkjet printing and heat-assisted in-situ curing of polydimethylsiloxane for smartphone microscopy,” (submitted).

Ming Li, Yong Du, Fusheng Zhao, Jianbo Zeng, Chandra Mohan, and Wei-Chuan Shih**, “Reagent- and separation-free measurements of urine creatinine concentration by stamping surface-enhanced Raman scattering (S-SERS),” (submitted).

Ji Qi, Pratik Motwani, Jianbo Zeng, John C Wolfe, and Wei-Chuan Shih**, “Morphological, plasmonic, and SERS characterization of DC-sputtered gold nanoislands,” (submitted).

Wei-Chuan Shih** and Kate L Bechtel, “Non-invasive glucose sensing by transcutaneous Raman spectroscopy,” (submitted).

Greggy M Santos, Fusheng Zhao, Jianbo Zeng, Ming Li, and Wei-Chuan Shih**, “Label-free, zeptomole cancer biomarker detection by surface-enhanced fluorescence on nano porous gold disk plasmonic nano particles,” (submitted).

Fusheng Zhao, Jianbo Zeng, Greggy M Santos, and Wei-Chuan Shih**, “In situ patterning of hierarchical nanoporous gold structures by in-plane dealloying, ” Materials Science and Engineering B (in revision).

Wei-Chuan Shih**, “A study of constrained regularization and its performance on non-invasive glucose sensing using Raman spectroscopy,” 2014 Journal of Innovative Optical Health Sciences (Accepted).

Jianbo Zeng, Fusheng Zhao, Ming Li, Chien-Hung Li, T. Randall Lee, and Wei-Chuan Shih**, “Morphological control and plasmonic tuning of nanoporous gold nanoparticles by surface modifications,” Journal of Materials Chemistry C DOI: 10.1039/C4TC02328E (First published online 11/14/2014).

Ji Qi, Kate L Bechtel, and Wei-Chuan Shih**, “Automated image curvature assessment and correction for high-throughput Raman spectroscopy and microscopy,” Biomedical Spectroscopy and Imaging 3(4): 359-368, 2014.

Md Masud Parvez Arnob, Fusheng Zhao, Jianbo Zeng, and Wei-Chuan Shih**, “Laser rapid thermal annealing enables tunable plasmonics in nanoporous gold nanoparticles,” Nanoscale 6(21), 12470-12475, 2014.

Narendran Sudheendran*, Ji Qi*, Eric D. Young, Alexander J. Lazar, Dina C. Lev, Raphael E. Pollock, Kirill V. Larin, Wei-Chuan Shih**, “High throughput Raman spectral imaging complements optical coherence tomography for tumor boundary detection,” Laser Physics Letters 11:105602, 2014 (*: Equal contribution).

Jianbo Zeng, Ji Qi, Fuquan Bai, Jorn Yu, and Wei-Chuan Shih**, “Analysis of ethyl and methyl centralite vibrational spectra for mapping organic gunshot residue,” Analyst 139(17), 4270-4278, 2014.

Jianbo Zeng, Fusheng Zhao, Chien-Hung Li, Yifei Li, Yan Yao, T. Randall Lee, and Wei-Chuan Shih**, “Internal and external morphology-dependent plasmonic properties in nanoporous gold disks,” RSC Advances 4, 36682-36688, 2014.

Ming Li, Fusheng Zhao, Jianbo Zeng, Ji Qi, Jing Lu, and Wei-Chuan Shih**, “Microfluidic surface-enhanced Raman scattering (SERS) sensor with monolithically integrated nanoporous gold disk (NPGD) arrays for rapid and label-free biomolecular detection,” Journal of Biomedical Optics 19(11), 111611, 2014.

Ji Qi, Jianbo Zeng, Fusheng Zhao, Steven Hsesheng Lin, Balakrishnan Raja, Ulrich Strych, Richard C. Willson, and Wei-Chuan Shih**, “Label-free, in situ SERS monitoring of individual DNA hybridization in microfluidics,” Nanoscale 6(15), 8521-8526, 2014.

Jing Yang, Xuebin Tan, Wei-Chuan Shih, and Mark Cheng, “A sandwich substrate for ultrasensitive SERS spectroscopic detection of folic acid / methotrexate,” Biomedical Microdevices 2014 DOI: 10.1007/s10544-014-9871-3 (Published on-line 5/25/14).

Fusheng Zhao, Jianbo Zeng, Md Masud Parvez Arnob, Po Sun, Ji Qi, Pratik Motwani, Mufaddal Gheewala, Chien-Hung Li, Andrew Paterson, Uli Strych, Balakrishnan Raja, Richard C. Willson, John C. Wolfe, T. Randall Lee, and Wei-Chuan Shih**, “Monolithic NPG nanoparticles with large surface area, tunable plasmonics, and high-density internal hot-spots,” Nanoscale 6, 8199-8207, 2014.

Ji Qi and Wei-Chuan Shih**, “Performance of line-scan Raman microscopy for high-throughput chemical imaging of cell population,” Applied Optics 53(13), 2881-2885, 2014.

Peter Liu*, Ji Qi*, Wei-Chuan Shih1**, and Kirill Larin2**, “Improvement of tissue analysis and classification using Optical Coherence Tomography combined with Raman spectroscopy,” Journal of Innovative Optical Health Sciences 2014, DOI: 10.1142/S1793545815500066 (In Press) (*: equal contribution; 1**: corresponding author; 2**: corresponding author).

Ming Li, Jing Lu, Ji Qi, Fusheng Zhao, Jianbo Zeng, Jorn Chi-Chung Yu, and Wei-Chuan Shih**, “Stamping surface-enhanced Raman spectroscopy for label-free, multiplexed, molecular sensing and imaging,” Journal of Biomedical Optics 19(5): 050501, 2014.

Greggy M. Santos, Fusheng Zhao, Jianbo Zeng, and Wei-Chuan Shih**, “Characterization of nanoporous gold disks for photothermal light harvesting and light-gated molecular release,” Nanoscale 6(11), 5718-5724, 2014.

Ji Qi, Pratik Motwani, Mufaddal Gheewala, Christopher Brennan, John C. Wolfe, and Wei-Chuan Shih**, “Surface-enhanced Raman spectroscopy using monolithic nanoporous gold disk substrates,” Nanoscale 5: 4105-4109, 2013. (Journal cover)

Ji Qi, Jingting Li, and Wei-Chuan Shih**, “High-speed hyperspectral Raman imaging for label-free compositional microanalysis,” Biomedical Optics Express 4(11): 2376-2383, 2013.

Ji Qi and Wei-Chuan Shih**, “Parallel Raman microspectroscopy using programmable multi-point illumination,” Optics Letters 37(8): 1289-1291, 2012.

Szu-Te Lin, Jack C. Wolfe, John A. Dani, and Wei-Chuan Shih**, “Flexible optitrode for localized light delivery and electrical recording,” Optics Letters 37(11): 1-3, 2012.

Albert B. Andrews, Wei-Chuan Shih, Oliver C. Mullins, and N. Koyo, “Molecular size determination of coal-derived asphaltene by fluorescence correlation spectroscopy,” Applied Spectroscopy: 65(12): 1348-1356, 2011.

Wei-Chuan Shih, Kate L Bechtel and Michael S Feld, “Intrinsic Raman spectroscopy for quantitative biological spectroscopy Part I: Theory and simulations,” Optics Express 16(17): 12726-12736, 2008. 

Kate L Bechtel, Wei-Chuan Shih and Michael S. Feld, “Intrinsic Raman spectroscopy for quantitative biological spectroscopy Part II: Experimental applications,” Optics Express 16(17): 12737-12745, 2008.

Wei-Chuan Shih and Albert B. Andrews, “Infrared contrast of crude oil covered water surfaces,” Optics Letters 33(24): 3019-3021, 2008. 

Wei-Chuan Shih and Albert B. Andrews, “Thermal infrared contrast of native and crude oil covered water surfaces,” Optics Express 16(4): 10535-10542, 2008. 

Wei-Chuan Shih, Kate L Bechtel and Michael S Feld, “Constrained regularization: A new method for multivariate calibration,” Analytical Chemistry, 79(1): 234-239, 2007. 

Obrad R. Šćepanović, Kate L. Bechtel, Abi S. Haka, Wei-Chuan Shih, Taewoon Koo, Andrew J. Berger, Michael S. Feld, “Determination of uncertainty in parameters extracted from single spectroscopic measurements,” Journal of Biomedical Optics, 12(6), 064012, 2007.

Wei-Chuan Shih, Sang-Gook Kim and George Barbastathis, “High resolution electrostatic analog tunable grating with a single-mask fabrication process,” IEEE/ASME Journal of Microelectromechanical Systems, vol. 15, no. 4, pp. 763-769, 2006.

Annika Enejder, Tom Scecina, Jeankun Oh, Martin Hunter, Wei-Chuan Shih, Slobadan Sasic, Gary Horowitz and Michael S.  Feld, “Raman spectroscopy for non-invasive glucose measurements,” Journal of Biomedical Optics, 10(3), 031114, 2005. 

Wei-Chuan Shih, Chee Wei Wong, Yungbae Jeon, Sang-Gook Kim and George Barbastathis, “MEMS tunable gratings with analog actuation,” Information Sciences, 149(1-3):31-40, 2003. 

Books: 

Wei-Chuan Shih**, “Hybrid fabrication makes better plasmonic nanostructures for SERS,” Photonics Spectra, August, 2013.

Wei-Chuan Shih, Kate L. Bechtel, and Michael S Feld, “Quantitative Biological Raman Spectroscopy,” in Handbook of Optical Sensing of Glucose in Biological Fluids and Tissues, Editor:  Valery V. Tuchin (Taylor & Francis 2008).

Wei-Chuan Shih, Kate L Bechtel, Michael S Feld, Mark A Arnold, Gary W Small, “Introduction to spectroscopy for noninvasive glucose sensing,” in Analytical Chemistry of In Vivo Glucose Measurements; Cunningham, D.; Stenken, JA, Eds.; Wiley Chemical Analysis Series (2009).

Wei-Chuan Shih, Kate L Bechtel, Michael S Feld, “ Non-invasive glucose sensing with Raman spectroscopy,” in Analytical Chemistry of In Vivo Glucose Measurements; Cunningham, D.; Stenken, JA, Eds.; Wiley Chemical Analysis Series (2009).

Patent/Patent Applications: 

62031516, Fabrication of lenses by droplet formation on a pre-heated surface (Provisional application). Inventor: Wei-Chuan Shih and Yulung Sung; Assignee: U. Houston
62004131, Nanoporous gold and silver nanoparticles and substrates for biomolecular sensing (Provisional application). Inventor: Wei-Chuan Shih and Richard C Willson; Assignee: U. Houston
61985984, Method of stamping surface-enhanced Raman spectroscopy for label-free, multiplexed, molecular sensing and imaging (Provisional application). Inventor: Wei-Chuan Shih and Ming Li; Assignee: U. Houston
61827192, Integrated thin-film optrode (Provisional application). Inventor: John C Wolfe, Mufaddal Gheewala, Wei-Chuan Shih; Assignee: U. Houston
61609451 Nanoporous gold nanoparticles as high-payload molecular cargo for cancer treatment and ultrahigh surface-to-volume sensor applications (Patent pending). Inventor: Wei-Chuan Shih. Assignee: U. Houston.
61585927 “Method and system for Raman microspectroscopy (Patent pending). Inventors: Wei-Chuan Shih. Asignee: U. Houston
US8661663 Method for manufacturing a multimodal neural probe. Inventors: John C Wolfe and Wei-Chuan Shih. Asignee: U. Houston.
US6975459 Micro-actuated adaptive diffractive composites. Inventors: G Barbastathis, SG Kim, Wei-Chuan Shih, CW Wong, YB Jeon. Asignee: MIT
US8124931 Method and apparatus for oil spill detection. Inventors: AB Andrews, Wei-Chuan Shih, M Clayton, OC Mullins. Asignee: Schlumberger Technology Corporation
US8362429 Method and apparatus for oil spill detection. Inventors: AB Andrews, Wei-Chuan Shih, M Clayton, OC Mullins. Asignee: Schlumberger Technology Corporation
US 8355767 Raman spectroscopy for non-invasive glucose measurements. Inventors: M. Hunter, A. Enejder, T. Scecina, M. Feld, Wei-Chuan Shih. Asignee: MIT

Refereed Conference Proceedings: 

"Flexible optitrode for localized light delivery and electrical recording,” SPIE Photonics West, San Francisco CA, Jan 2013.
“Monolithic porous gold nanostructures as surface-enhanced Raman spectroscopy substrates for molecular and biosensing,” SPIE Photonics West, San Francisco CA, Jan 2013.
“Sparse-sampling parallel Raman/SERS microspectroscopy for high-throughput molecular analysis of micro and nanoparticles,” SPIE Photonics West, San Francisco CA, Jan 2013.
"High throughput Raman and surface-enhanced Raman microscopy,” SPIE Photonics West, San Francisco CA, Jan 2012.
“Integrated multi-sensing optrode for neural stimulation and recording,” SPIE Photonics West, San Francisco CA, Jan 2012.
"Oil spill sensor using multispectral infrared imaging via l1 minimization," ICASSP, Prague CZ, May 2011.
“A flexible optrode for deep brain neurophotonics,” IEEE International Conference on Neural Engineering, Cancun, Mexico, May 2011.
“Offshore stand-off oil spill monitoring using passive optical imaging,” Proc. SPIE 7312, 73120V, 2009.
“Intrinsic Raman spectroscopy improves analyte concentration measurements in turbid media,” Biomedical Optics Topical Meeting by Optical Society of America, Fort Lauderdale, FL, Mar 2006.
“Optical diversity by nanoscale actuation,” IEEE NANO, San Francisco CA, 2003.
Analog tunable gratings with nanometer resolution,” Solid-state Sensor and Actuator Workshop, Hilton Head SC, Jun 2002.
“Electrostatic and piezoelectric analog tunable diffractive gratings,” Lasers and Electro-Optics (CLEO), Long Beach CA, May 2002.
“Analog tunable diffractive grating with milliradian resolution,” Optical Fiber Communication Conference (OFC), Anaheim CA, Mar 2002.

News: 

Major grants:
- DOI Award 2015
- NIH R21 grant 2014
- NSF CAREER Award 2012
- NASA CAREER Award 2012
- GoMRI-RFPII 2012

Multiple positions for PhD Research Assistant and Postdoc (Start immediately):
Suitable expertise: Optics, photonics, plasmonics, spectroscopy, imaging, FDTD, microfluidics, nanofabrication, microfabrication, biophotonics, biodemical optics.